Israeli Study: 1 of 2.5 Million Vaccinated for COVID Develop Severe Myocarditis

A man receives a dose of the COVID-19 vaccine at a temporary health care center in Yerushalayim, Oct. 3. (Yonatan Sindel/Flash90)

Just one out of 2.5 million Israelis aged 16 and over who were vaccinated through Clalit Health Services suffered from serious heart inflammation after the fact, according to new research published in The New England Journal of Medicine on Wednesday. The remaining cases were either moderate or mild. Young men aged 16 to 29 were the most likely to develop myocarditis.

The heart inflammation was identified in 54 individuals, three of whom were women. For every 100,000 men inoculated, 4.12 suffered from the side effect. Among women, 0.23 of 100,000 women experienced the side effect.

Among those who experienced heart inflammation, 69% did so after their second dose.

Among young men aged 16 to 29 who received the vaccine, the age group most likely to experience the side effect, 10.7 of every 100,000 suffered from myocarditis.

The study was unique in that it followed those who experienced myocarditis for a period of 12 weeks.

67% – 41 individuals – of those afflicted experienced mild heart inflammation, meaning they exhibited mild symptoms and showed no signs of damage to their heart muscle, while 22% – 12 – experienced moderate symptoms, meaning they exhibited mild symptoms and demonstrated mild damage to their heart muscle. Just one patient suffered from severe myocarditis, exhibiting severe symptoms and serious damage to their heart muscle.

A majority of patients, 71%, did not exhibit any signs of damage to cardiac function at any stage when undergoing an echocardiogram, something 90% of patients underwent while hospitalized. Of the 29% of patients who were found to exhibit signs of impaired cardiac function, over 85% experienced mild to moderate damage while the remaining individuals were found to have their cardiac function return to normal shortly after being released from the hospital. The one individual who experienced serious damage was the exception.

That individual, a young man in his 20s, needed to be hooked up to an ECMO machine, although he was taken off the machine later on.

The research was conducted in cooperation with Professor Ran Kornowski, director of the Rabin Medical Center’s Cardiology Center, hospital physicians, and researchers from the Clalit Research Institute.

“In this study, we can see the morbidity rated in various age groups and the fact that cardiac function was not impaired in the short- and medium-term. It is also important to remember that in the earlier study, we also demonstrated increased morbidity rates for myocarditis after contracting the coronavirus,” Professor Ran Balicer, Clalit Research Institute director and chief innovation officer at Clali Healthcare Services and a member of the expert panel advising the government on the coronavirus, said.

A separate Israeli research study carried out among 5,000 employees at Shema Medical Center at Tel Hashomer that appeared in The New England Journal of Medicine pointed to antibody levels diminishing for a period of six months after inoculation. The decrease in antibody levels was found to be significant and ongoing. The research found that the antibody levels decreased sharply at first, and from the third month after receiving the second dose of the vaccine although at more moderate rates.


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