The Syrian air force shot down a “hostile target” that was flying over the town of Kiswah, south of the capital Damascus, state media claimed on Thursday night.
A number of pro-Iranian militia bases and Iranian weapons caches in southern Syria were targeted by Israeli planes, according to the Al-Arabiya news site.
The state media quoted a military source but did not specify what the target was or where it came from.
Syrian opposition sources on the ground said the area was close to where the Iranian-backed Hezbollah has a powerful presence with several bases.
The Israeli military declined comment, in line with its standing policy on such matters.
Videos from Syria circulated on social media showed multiple Syrian interceptor missiles being fired into the air south of Damascus.
Israel, concerned that Iran’s growing presence in Syria poses a threat to its own security, has struck dozens of Iranian and Iran-backed positions in Syria over the course of the seven-year conflict.