Smoke billowed from a midtown Manhattan building near Times Square as firefighters responded to a fire in the duct work.
One person was taken to the hospital after having difficulty breathing.
The Fire Department of New York says the call came in at 7:38 a.m. Sunday about the fire at 145 W. 45th St, a 12-story commercial building.
People in the hotel next door were also evacuated.
The fire was declared under control shortly before 9 a.m.
Officials said in addition to the person taken to the hospital, two others were treated at the scene.